| Father | Edmund Lewis (1772 - 1820) |
| Mother | Abigail Bigelow Prentiss (1776 - 1851) |
| Sibling | Edmund Lewis (1793 - 1810) |
| Sibling | William Russell Lewis (1794 - ) |
| Sibling | Joshua Prentiss Lewis (1795 - 1796) |
| Sibling | Joshua Prentiss Lewis (1797 - 1823) |
| Sibling | John Lewis (1799 - 1885) |
| Sibling | Abagail Lewis (1800 - 1801) |
| Sibling | Prentiss Lewis (1802 - 1803) |
| Sibling | Philip Bessom Lewis (1804 - 1877) |
| Sibling | Abagail B. Lewis (1805 - 1887) |
| Sibling | Henry Prentiss Lewis (1807 - 1861) |
| Sibling | William R. Lewis (1809 - 1810) |
| Sibling | Harriet C. Lewis (1813 - 1896) |
| Sibling | Tabitha Russell Lewis (1815 - 1897) |
| Sibling | William Edmund Lewis (1815 - 1842) |
| Sibling | Charlotte Caroline Lewis (1819 - 1900) |