| Father | William Overton Rutherford Sr (1727 - 1801) |
| Mother | Ursula Parrish (1732 - 1801) |
| Sibling | Randolph Rutherford (1758 - 1841) |
| Sibling | Samuel R Rutherford (1768 - 1839) |
| Sibling | Archibald Hamilton Rutherford (1768 - 1825) |
| Sibling | Archelaus Rutherford (1765 - ) |
| Sibling | Ursula Rutherford (1770 - 1828) |
| Sibling | Absalom Rutherford (1763 - 1841) |
| Sibling | Benjamin Rutherford (1770 - 1860) |
| Sibling | William Rutherford (1763 - 1813) |
| Sibling | Finney Phineas Rutherford (1773 - 1861) |
| Sibling | Thomas Rutherford (1760 - 1845) |
| Sibling | John Rutherford (1760 - 1839) |
| Sibling | Lossane Rutherford (1756 - ) |
| Sibling | David Rutherford ( - ) |
| Sibling | Julius Rutherford (1756 - 1831) |
| Sibling | Archibald Rutherford (1754 - 1838) |
| Sibling | Sarah Davenport (1751 - 1801) |
| Sibling | John Rutherford ( - ) |
| Sibling | Mary Rutherford (1750 - ) |
| Sibling | Joseph Rutherford ( - ) |
| Sibling | Susannah Rutherford (1750 - 1839) |