| Father | Col. Thomas Mackay Sprigg PRATHER of "Conegocheaugue" (1704 - 1785) |
| Mother | Elizabeth CLAGGETT (1708 - 1767) |
| Sibling | Thomas Claggett PRATHER (1726 - 1758) |
| Sibling | Richard PRATHER of "Richard's Choice" (1727 - 1789) |
| Sibling | Jonathan PRATHER (1728 - 1801) |
| Sibling | Mary "Polly" PRATHER (1730 - 1790) |
| Sibling | Capt. Basil William PRATHER (1731 - 1803) |
| Sibling | Henry Abram PRATHER of Cumberland Co., PA (1732 - 1775) |
| Sibling | Eleanor PRATHER twin (1734 - 1783) |
| Sibling | Martha Sprigg PRATHER twin (1734 - 1734) |
| Sibling | Charles PRATHER of Wellsburg, Brooke Co., WV (1735 - 1810) |
| Sibling | Capt. James PRATHER (1737 - 1816) |
| Sibling | Sarah PRATHER (1739 - 1783) |
| Sibling | Joanne "Ann" PRATHER (1740 - 1797) |
| Sibling | Elizabeth PRATHER (1742 - 1783) |